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Aliskiren Hydrochloride

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Formula: C30H53N3O6.HCl
CAS: 173399-03-6
search Element: hydrochloride aliskiren
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Identification

Structural Formula
Aliskiren Hydrochloride
CAS:
173399-03-6
EINECS:
Molecular Formula:
C30H53N3O6.HCl
MDL:
MFCD13185885
SMILES:
CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.Cl
Synonym:
(2s,4s,5s,7s)-5-amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide hydrochloride ; (αs,γs,δs,zs)-δ-amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide hydrochloride ; tekturna hydrochloride ; aliskiren hydrochloride ; rasilez hydrochloride ; (2s,4s,5s,7s)-7-(3-(3-methoxypropoxy)-4-methoxybenzyl)-5-amino-n-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride


Description

Aliskiren hydrochloride is a direct renin inhibitor with an IC50 = 0.72 nM. Renin is the first enzyme in the renin-angiotensin-aldosterone system (RAAS) and cleaves angiotensinogen, an inactive peptide, into angiotensin I. Inhibition of renin prevents this cleavage and subsequent activiation of angiotensin II receptors.


Suppliers

Santa Cruz Biotechnology, Inc.
207268
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CAS equal suppliers

(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
Leap Chem Co., Ltd
LC50616151848

Prices & Availability




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Properties for Aliskiren Hydrochloride

Molecular Weight:
588.22 g·mol−1
Melting point:
76-78 °C
Solubility:
Soluble in methanol, chloroform, and water.
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Safety & Transport Information

Storage temperature :
Hygroscopic, -20 °C Freezer, Under Inert Atmosphere
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Alternative Distributors of [Aliskiren Hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Clearsynth Canada INC.

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