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Alamethicin

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Formula: C92H150N22O25
CAS: 27061-78-5
search Element: alamethicin
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Identification

Structural Formula
Alamethicin
CAS:
27061-78-5
EINECS:
Molecular Formula:
C92H150N22O25
MDL:
MFCD00151517
Synonym:
almethicin, antibiotic u-22324, 6-(2-methylalanine)-8-l-leucine-9-de-l-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-l-glutamine-19-(n(1)-(1-(hydroxymethyl)-3-methylbutyl)-l-glutamamide)-] ; alamethicinresearch grade ; alamethicin, ready made solution from trichoderma viride ; (3s,12r)-1-((s)-1-((6s,12s,15s,21s,30s)-1-((r)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1 ; ac-2-meala-l-pro-2-meala-l-ala-2-meala-l-ala-l-glu(nh2)-2-meala-l-val-2-meala-gly-l-leu-2-meala-l-pro-l-val-2-meala-2-meala-l-glu-l-glu(nh2)-phenylalaninol ; alamethicin from trichoderma viride ; peptaibol complex. additional synonyms for the major component, alamethicin i: alamethicin f30, alamethicin-gamma, u 22324 ; alamethicin (u-22324)


Description

Alpha-helical peptide antibiotic produced by the fungus Trichoderma viride. It forms tetra- and hexameric voltage gated ion channels in membranes and can mimic nerve action potential across artificial membrandes. 1. Fox, R.O. Jr, Richards, F.M., A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution. Nature. 1982; 300(5890):325-30. 2. Mathew, M.K., Balaram P., Alamethicin and related membrane channel forming polypeptides. Mol Cell Biochem. 1983; 50(1):47-64. 3. Stella, L., et al., Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues. Chem Biodivers. 2007; 4(6):1299-312.


Suppliers

Iris Biotech GmbH
LS-1075
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Santa Cruz Biotechnology, Inc.
sc-200094
Dayang Chem (Hangzhou) Co.,Ltd.
DC3411364
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CAS equal suppliers

Alamethicin (U-22324)
Santa Cruz Biotechnology, Inc.
200094

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Data is processed


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Properties for Alamethicin

Molecular Weight:
1964.3078 g·mol−1
Melting point:
263-265° C
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Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
Safety Codes:
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
2-8°C
RID/ADR certification :
UN 3462 6.1 / PG 3
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Alternative Distributors of [Alamethicin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Fermentek Ltd.

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