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AICAR

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Formula: C9H14N4O5
CAS: 2627-69-2
search Element: aicar

Identification

Structural Formula
AICAR
CAS:
2627-69-2
EINECS:
220-097-5
Molecular Formula:
C9H14N4O5
MDL:
MFCD00869751
SMILES:
NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](CO)C(O)[C@@H]1O
Synonym:
ampkb ; prkaa ; ampk ; ampk1 ; aakg ; ampk2 ; wpws ; aicar ; cmh6 ; aakg2


Description

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.


Suppliers

Shandong Lanhai Industry Co.,Ltd.
SLIC165825
H&Z Industry Co.,Ltd
HIC100400
Chemlyte Solutions
CS90270
Sancai Industry Co.,Ltd.
SIC120480
Zehao Industry Co., Ltd.
ZI120360
Amadis Chemical Company Limited
ACCL155775
Santa Cruz Biotechnology, Inc.
200659
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Daming Changda Co., Ltd.
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Prices & Availability




Data is processed


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Properties for AICAR

Molecular Weight:
258.23 g·mol−1
Density:
2.06 g/cm3
Melting point:
214-215 °C
Boiling point:
726.32° C at 760 mmHg
Solubility:
H2O: >10 mg/mL
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
R61 - May cause harm to the unborn child
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Symbols:
Xi, T
Hazard symbol T Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [AICAR]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Finetech Industry Limited | TCS INDUSTRY LTD. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Brightol International Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Shanghai Insight Chemicals Co., Ltd. | Wanko Chemical Co., Ltd. | Tianjin Security Technology Development Ltd.

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