p53 Activator III, RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Renal carcinoma research has demonstrated that RITA induces DNA damage, and DNA-DNA, DNA-protein crosslinks. Furthermore, low concentrations of RITA caused cell cycle arrest in G0-G1 and G2-M, and elevated p53 and p21(WAF1) protein levels in renal carcinoma studies. At higher concentrations RITA has been reported to cause an increases of p53 protein levels, reduces p21(WAF1) protein levels, and induce apoptosis.
Soluble in DMSO (58 mg/ml at 25° C), ethanol (8 mg/ml at 25° C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25° C).
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Safety & Transport Information
Storage temperature :
Store at -20 °C
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Alternative Distributors of [p53 Activator III, RITA]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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