Acivicin | CAS 42228-92-2 | Chemical-Suppliers

Element: acivicin

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C-S » Chemicals » acivicin-PX81598

Identification

Acivicin

CAS:

42228-92-2

EINECS:

Molecular Formula:

C₅H₇ClN₂O₃

MDL:

MFCD00058450

SMILES:

C1[C@H](ON=C1Cl)[C@@H](C(=O)O)N

Synonym:

dihydroxy-5-isoxazoleaceticacid ; (αs,5s)- ; (a-s,5s)-a-amino-3-chloro-4,5-dihydro-5-isoxazoleaceticacid ; nsc-163501 ; u-42126 ; acivicinacivicin ; antibiotic u-42126 ; acivicine ; at-125 ; acivicin ; 5-isoxazoleacetic acid,a-amino-3-chloro-4,5-dihydro-, (as,5s)- ; antibioticat125 ; antibiotic at 125 ; 5-isoxazoleaceticacid, a-amino-3-chloro-4,5-dihydro-,[s-(r*,r*)]-

Description

Acivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to suggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID₅₀ = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

A0126.00

Santa Cruz Biotechnology, Inc.

200498

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CAS equal suppliers

alpha-Amino-3-chloro-4,5-dihydro-, (as,5S)-5-isoxazoleacetic acid

Salsbury Chemicals, Inc.

SC1248037440

Prices & Availability

Data is processed

Properties for Acivicin

Molecular Weight:

178.57 g·mol−1

Density:

1.85 g/cm3

Melting point:

>200 °C (dec.)

Boiling point:

341.6 °C at 760 mmHg

Flash point:

160.4 °C

Solubility:

Soluble in water (18 mg/mL, max), and 1 N HCl (50 mg/mL, with heat as needed).

Physical Description:

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed

Safety Codes:

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

3172

Alternative Distributors of [Acivicin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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