Acetyl Podocarpic Acid Anhydride | CAS 344327-48-6

Element: podocarpic anhydride acetyl acid

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C-S » Chemicals » acetyl-podocarpic-acid-anhydride-PX80451

Identification

Acetyl Podocarpic Acid Anhydride

CAS:

344327-48-6

EINECS:

Molecular Formula:

C₃₈H₄₆O₇

MDL:

SMILES:

CC(=O)OC1=CC2=C(CC[C@@H]3[C@@]2(CCC[C@]3(C)C(=O)OC(=O)[C@]4(CCC[C@]5([C@H]4CCC6=C5C=C(C=C6)OC(=O)C)C)C)C)C=C1

Synonym:

Description

Acetyl podocarpic acid anhydride (APD) is a potent, semi-synthetic liver X receptor (LXR) agonist derived from extracts of the mayapple. APD forms a heterodimer with the retinoid X receptor (RXR), and together these compounds, acting through LXR, induce the expression of the ABCA1 reverse cholesterol transporter and inhibit the overall absorption of cholesterol (ED₅₀ = 1 nM). In transient transactivation assays, acetyl podocarpic acid anhydride was found to be approximately 1,000 times more potent than 22(R)-hydroxy cholesterol. APD can be used as a positive control for the testing of LXR agonists.

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Properties for Acetyl Podocarpic Acid Anhydride

Molecular Weight:

614.75 g·mol−1

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Alternative Distributors of [Acetyl Podocarpic Acid Anhydride]

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MSDS:

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