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N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt

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Formula: C20H38N6O4
CAS: 103476-89-7

Identification

Structural Formula
N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
CAS:
103476-89-7
EINECS:
Molecular Formula:
C20H38N6O4
MDL:
MFCD00037012
Synonym:


Description

A potent, reversible inhibitor of serine and cysteine proteases. It showed little to no inhibition activity against: pepsin, cathepsins A and D and alpha-chymotrypsin. All three salt forms are equally effective, when adjusted to their molarity. Potential targets: Calpain, Plasmin, Trypsin, Papain, Cathepsin B, H, L, Kallikrein, Thrombin References: J. H. Sher, A. Stracher, S. A. Shafig, J. Hardy-Stashin (1981) Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin. Proc Natl Acad Sci USA, 78(12), 7742-4. R. M. Schultzz, P. Varma-Nelsons, R. Ortiz, K. A. Kozlowskin, A. T. Orawski, P. Pagast, A. Frankfater (1989) Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain. J Biol Chem., 264(3), 1497­507.


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