N-(4-Acetamidophenyl)indomethacin Amide | CAS 261766-23-8

Element: acetamidophenyl indomethacin amide

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Identification

N-(4-Acetamidophenyl)indomethacin Amide

CAS:

261766-23-8

EINECS:

Molecular Formula:

C₂₇H₂₄ClN₃O₄

MDL:

SMILES:

COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(=O)NC3=CC=C(NC(C)=O)C=C3)C2=C1

Synonym:

1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-

Description

N-(4-Acetamidophenyl)indomethacin Amide is a potent and selective reversible Cox-2 inhibitor. N-(4-Acetamidophenyl)indomethacin Amide inhibits human Cox-2 with IC₅₀ of 0.1 μM and ovine Cox-2 with IC₅₀ of 0.625 μM. N-(4-Acetamidophenyl)indomethacin Amide is about 400 times less potent as an inhibitor of human Cox-1 and 80 times less potent as an inhibitor of ovine Cox-1. N-(4-Acetamidophenyl)indomethacin Amide shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

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Santa Cruz Biotechnology, Inc.

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Properties for N-(4-Acetamidophenyl)indomethacin Amide

Molecular Weight:

489.95 g·mol−1

Melting point:

256-257°C (lit.)

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Alternative Distributors of [N-(4-Acetamidophenyl)indomethacin Amide]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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N-(4-Acetamidophenyl)indomethacin Amide (N-(4-Acetamidophenyl)-1-p-chlorobenzoyl-5-methoxy-2-methylindole-3-acetamide)