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OSI-420, Free Base (Desmethyl Erlotinib)

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Formula: C21H21N3O4
CAS: 183321-86-0

Identification

Structural Formula
OSI-420, Free Base (Desmethyl Erlotinib)
CAS:
183321-86-0
EINECS:
Molecular Formula:
C21H21N3O4
MDL:
MFCD09841129
SMILES:
COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
Synonym:
Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-


Description

OSI-420 is a metabolite of Erlotinib. Erlontinib potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib and rapamycin produced a synergistic inhibitory effect on cell growth.


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Santa Cruz Biotechnology, Inc.
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Properties for OSI-420, Free Base (Desmethyl Erlotinib)

Molecular Weight:
379.41 g·mol−1
Density:
1.31 g/cm3 (Predicted)
Melting point:
140-142° C
Boiling point:
572.81° C at 760 mmHg (Predicted)
Solubility:
Soluble in methanol, and DMSO.
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Safety & Transport Information

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Alternative Distributors of [OSI-420, Free Base (Desmethyl Erlotinib)]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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