1-Methyl-D-tryptophan | CAS 110117-83-4

Element: tryptophan methyl

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C-S » Chemicals » methyl-tryptophan-PX1176946

Identification

1-Methyl-D-tryptophan

CAS:

110117-83-4

EINECS:

Molecular Formula:

C₁₂H₁₄N₂O₂

MDL:

MFCD00274271

SMILES:

CN1C=C(C[C@@H](N)C(O)=O)C2=CC=CC=C12

Synonym:

indoximod ; nlg-8189 ; indoximod (nlg-8189 ) ; 1-methyl-d-tryptophane ; 1-me-d-trp ; (r)-2-amino-3-(1-methyl-1h-indol-3-yl)propanoic acid ; 1-methyl-d-tryptophan 95% ; d-trp(me)-oh ; 1-methyl-d-tryptophan

Description

1-Methyl-D-tryptophan is an inhibitor of the enzymes and indolamine 2,3-dioxygenase 1 (IDO) and indolamine 2,3-dioxygenase 2 (INDOL1), with selectivity for INDOL1. The enzymes perform similar transformations and are responsible for catalyzing the rate-limiting step of oxidative tryptophan catabolism in the kynurenine pathway. IDO activity is correlated with an induction of tolerance and immunosuppresion through activation of regulatory T cells by metabolites generated from tryptophan catabolism. Inhibition of IDO by 1-Methyl-D-tryptophan blocks this induced immune suppression, which has shown utility in suppressing acquired immunities of tumors and indicates potential for chemical intervention of chronic inflammatory diseases.

Suppliers

H&Z Industry Co.,Ltd

HIC4201680

Hangzhou Ocean Chemical Co., Ltd.

HOC6932772

Capot Chemical Co., Ltd.

10617

Leap Chem Co., Ltd

LC3781134

Santa Cruz Biotechnology, Inc.

200313

Dayang Chem (Hangzhou) Co.,Ltd.

DC6512604

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CAS equal suppliers

Indoximod

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC34314

Indoximod

ShangHai Biochempartner Co., Ltd.

BCP08015

Indoximod

Excenen Pharmatech Co., Ltd.

EN-3451

Indoximod

CSNpharm, Inc.

CSN15702

D-Trp(Me)-OH

SINO High Goal Chemical Technology Co., Ltd.

SHGCT15849504

D-tryptophan, 1-methyl-

Angene International Limited

AGN-PC-0NXAXM

Prices & Availability

Data is processed

Properties for 1-Methyl-D-tryptophan

Molecular Weight:

218.25 g·mol−1

Density:

1.28

Melting point:

242-245 °C(lit.)

Boiling point:

429.30° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (slightly), and acetic acid.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [1-Methyl-D-tryptophan]

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