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Y-27632, free base

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Formula: C14H21N3O.2HCl
CAS: 146986-50-7
search Element: 27632 base free

Identification

Structural Formula
Y-27632, free base
CAS:
146986-50-7
EINECS:
Molecular Formula:
C14H21N3O.2HCl
MDL:
MFCD03490488
SMILES:
C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
Synonym:


Description

Y-27632, free base is the free base form of Y-27632 dihydrochloride, a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 also inhibits protein kinase C related kinase, PRK2.


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Santa Cruz Biotechnology, Inc.
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Prices & Availability




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Properties for Y-27632, free base

Molecular Weight:
338.28025 g·mol−1
Solubility:
Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

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Alternative Distributors of [Y-27632, free base]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Shanghai Sun-shine Chemical Technology Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd.

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