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AEBSF hydrochloride

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Formula: C8H11ClFNO2S
CAS: 30827-99-7
search Element: hydrochloride aebsf

Identification

Structural Formula
AEBSF hydrochloride
CAS:
30827-99-7
EINECS:
Molecular Formula:
C8H11ClFNO2S
MDL:
MFCD00132962
SMILES:
C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Synonym:
timtec-bb sbb003219 ; aebsf hydrochloride ; aebsf ; aebsf hci ; pefabloc sc plus ; aebsf hcl ; 4-(2-aminoetyl)-benzen ; 4-(2-aminoethyl)benz ; pefabloc(r) sc ; pefabloc sc


Description

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF and DFP.


Suppliers

Shandong Ench Chemical Co.,Ltd
SECC11405700
Aea.ltd
A266532
BOC Sciences
BS4561368
Santa Cruz Biotechnology, Inc.
202041
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Prices & Availability




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Properties for AEBSF hydrochloride

Molecular Weight:
239.69 g·mol−1
Melting point:
175-177 °C
Solubility:
Soluble in water (10 g/L) at 20° C, and DMSO (50 mg/ml).
Physical Description:
white powder
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Safety & Transport Information

Risk Codes:
R34 - Causes burns
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
8
Hazard Symbols:
C, Xi
Hazard symbol C Hazard symbol Xi
Storage temperature :
0-6°C
RID/ADR certification :
UN 3261
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Alternative Distributors of [AEBSF hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Molekula GmbH | Carl Roth GmbH + Co KG | Jinan Haohua Industry Co., Ltd. | D&P Global Chemical Co., Ltd

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